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. 2021 Jun;36(6):917-925.
doi: 10.1002/gps.5494. Epub 2021 Jan 16.

Benzodiazepines and antidepressants: Effects on cognitive and functional decline in Alzheimer's disease and Lewy body dementia

Miguel Germán Borda  1   2   3 , Alberto Jaramillo-Jimenez  1   3   4 , Ragnhild Oesterhus  1   5 , Jose Manuel Santacruz  2   6   7 , Diego Alejandro Tovar-Rios  1   8   9 , Hogne Soennesyn  1 , Carlos Alberto Cano-Gutierrez  2   10 , Audun Osland Vik-Mo  1   5 , Dag Aarsland  1   11
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Benzodiazepines and antidepressants: Effects on cognitive and functional decline in Alzheimer's disease and Lewy body dementia

Miguel Germán Borda et al. Int J Geriatr Psychiatry. 2021 Jun.

Abstract

Objectives: We aim to study the effects of the prescription of benzodiazepines and antidepressants on cognitive and functional decline in older adults living with Alzheimer's disease (AD) and Lewy body dementia (LBD) over a 5-year follow-up.

Methods: This is a longitudinal analysis of a Norwegian cohort study entitled "The Dementia Study of Western Norway" (DemVest). We included 196 patients newly diagnosed with AD (n = 111) and LBD (n = 85), followed annually for 5 years. Three prescription groups were defined: only benzodiazepines (BZD), only antidepressants (ADep), and the combination of benzodiazepines and antidepressants (BZD-ADep). Linear mixed-effects models were conducted to analyze the effect of the defined groups on the outcomes. The outcomes were functional decline, measured by the Rapid Disability Rating Scale-2, and cognition measured with the Mini-Mental State Examination.

Results: Prescription of the combination of benzodiazepines and antidepressants in LBD was associated with faster functional decline. In AD, the prescription of BZD and BZD-ADep was associated with greater functional deterioration. ADep alone did not show positive or negative significant associations with the studied outcomes.

Conclusions: BZD and especially the combination of BZD and ADep are associated with functional decline in AD and LBD and should be used cautiously.

Keywords: Alzheimer's disease; Antidepressive Agents; Lewy body dementia; activities of daily living; benzodiazepines; cognitive decline; dementia; functional disability; hypnotics and sedatives.

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References

REFERENCES

    1. Orgeta V , Mukadam N , Sommerlad A , Livingston G . The lancet commission on dementia prevention, intervention, and care: a call for action. Ir J Psychol Med. 2019;36(2):85-88.
    1. Alzheimer’s-Association. Alzheimer's Disease facts and figures. Alzheimers Dement. 2020;16(2):391+.
    1. Mueller C , Ballard C , Corbett A , Aarsland D . The prognosis of dementia with Lewy bodies. Lancet Neurol. 2017;16(5):390-398.
    1. Rongve A , Soennesyn H , Skogseth R , et al. Cognitive decline in dementia with Lewy bodies: a 5-year prospective cohort study. BMJ Open. 2016;6:e010357.
    1. Borda MG , Soennesyn H , Steves CJ , Osland Vik-Mo A , Pérez-Zepeda MU , Aarsland D . Frailty in older adults with mild dementia: dementia with Lewy bodies and Alzheimer’s disease. Dementia Geriatric Cognitive Disord Extra. 2019;9(1):176-183.

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