Aloe Vera; A new treatment for atrophic vaginitis, A randomized double-blinded controlled trial

J Ethnopharmacol. 2021 Apr 24;270:113760. doi: 10.1016/j.jep.2020.113760. Epub 2020 Dec 28.


Aim of the study: Vaginal atrophy is of the most common problems during menopause with significant psychosocial and medical consequences. Estrogen as an approved therapy for vaginal atrophy can be associated with adverse effects and several contraindications in menopause patients. The aim is to compare the effect of Aloe Vera vaginal cream with commercially available estrogen vaginal cream for management of vaginal atrophy in menopause females.

Materials and methods: This is a double-blinded randomized controlled trial on 60menopause female with complaints of vaginal atrophy symptoms. Subjects were randomly allocated in two groups of 30 patients, named as estrogen and Aloe Vera groups. Vaginal health index (VHI), maturity value (MV), vaginal cytologic smear, transvaginal sonography (TVS) and severity of symptoms related to vaginal atrophy were assessed before and after 6-weeks of vaginal cream administration.

Results: Comparison of MV before and after treatment revealed that superficial cells were significantly increased after administration of both vaginal cream (6.67 VS 54.33 in Aloe Vera group; 4.33 VS 59.67 in estrogen group). In addition, VHI (13.83 vs 20.13 in Aloe Vera group; 13.97 vs 19.93 in estrogen group) and symptoms of vaginal atrophy (3.63 vs 1.10 in Aloe Vera group; 3.90 vs 0.66 in estrogen groups) were also significantly improved after treatment in both groups. There was no significant difference between groups after treatment except for fluid volume with a superiority in Aloe Vera group (P-value = 0.004) CONCLUSION: Aloe Vera vaginal cream can be as effective as estrogen vaginal cream in the management of vaginal atrophy in menopause females.

Keywords: Aloe Vera; Estrogen; Maturity value (MV); Menopause patients; Vaginal atrophy; Vaginal health index (VHI).

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Intravaginal
  • Aged
  • Aloe*
  • Atrophic Vaginitis / drug therapy*
  • Double-Blind Method
  • Estrogens / administration & dosage
  • Female
  • Humans
  • Menopause / drug effects
  • Middle Aged
  • Plant Preparations / administration & dosage*
  • Treatment Outcome
  • Vaginal Creams, Foams, and Jellies / administration & dosage*


  • Estrogens
  • Plant Preparations
  • Vaginal Creams, Foams, and Jellies