CD4 Count at Entry into Care and at Antiretroviral Therapy Prescription among Adults with Human Immunodeficiency Virus in the United States, 2005-2018

Clin Infect Dis. 2021 Oct 5;73(7):e2334-e2337. doi: 10.1093/cid/ciaa1904.


From 2005 to 2018, among 32013 adults with human immunodeficiency virus entering care, median time to antiretroviral therapy (ART) prescription declined from 69 to 6 days, CD4 count at entry into care increased from 300 to 362 cells/μL, and CD4 count at ART prescription increased from 160 to 364 cells/μL.

Keywords: CD4 count; HIV; antiretroviral therapy; treat all; universal treatment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Anti-HIV Agents* / therapeutic use
  • Antiretroviral Therapy, Highly Active
  • CD4 Lymphocyte Count
  • HIV
  • HIV Infections* / drug therapy
  • HIV Infections* / epidemiology
  • Humans
  • Prescriptions
  • United States / epidemiology


  • Anti-HIV Agents