Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats

Exp Neurol. 1988 Feb;99(2):440-6. doi: 10.1016/0014-4886(88)90160-4.

Abstract

A sonicated liposome suspension of gamma-aminobutyric acid (GABA) and phosphatidylserine (liposome-entrapped GABA), intraperitoneally administered in rats, inhibited EEG epileptic activity induced by penicillin, whereas GABA did not. A significant increase (20.4%) in brain radioactivity accumulation occurred at 5 min after i.p. administration of [14C]GABA associated with phosphatidylserine in comparison with the administration of [14C]GABA; such an increase persisted after 20 min. However, the accumulation of radioactivity into brain synaptosomes demonstrated a 24.1% increase at 5 min and subsequently showed a 43.3% increase at 20 min after injection of liposome-entrapped GABA. The above findings suggest that phosphatidylserine stimulates exogenous GABA uptake into brain GABAergic nerve terminals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / metabolism
  • Liposomes / administration & dosage
  • Male
  • Phosphatidylserines / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Synaptosomes / metabolism*
  • gamma-Aminobutyric Acid / pharmacokinetics*

Substances

  • Liposomes
  • Phosphatidylserines
  • gamma-Aminobutyric Acid