Management of acute spinal cord compression in multiple myeloma

Bo Chen; Lin Cai; Fuling Zhou

doi:10.1016/j.critrevonc.2020.103205

Management of acute spinal cord compression in multiple myeloma

Crit Rev Oncol Hematol. 2021 Apr:160:103205. doi: 10.1016/j.critrevonc.2020.103205. Epub 2020 Dec 30.

Authors

Bo Chen¹, Lin Cai², Fuling Zhou³

Affiliations

¹ Department of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, China.
² Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
³ Department of Hematology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, China. Electronic address: zhoufuling@whu.edu.cn.

PMID: 33387626
DOI: 10.1016/j.critrevonc.2020.103205

Abstract

Spinal cord compression (SCC) is a devastating complication of multiple myeloma and has the potential to cause loss of neurological function. The common symptoms of SCC are back pain, motor weakness, and sensory change. Once diagnosed, the patient should be managed as soon as possible to prevent permanent loss of neurological function. Currently, there have been a number of studies describing the mechanism and management experience of SCC in patients with myeloma. The clinical features, diagnostic strategies, and the roles of different therapeutic options are herein reviewed.

Keywords: Anti-plasma cell therapies; Multiple myeloma; Radiation therapy; Spinal cord compression; Surgery.

Publication types

Review

MeSH terms

Humans
Multiple Myeloma* / complications
Multiple Myeloma* / therapy
Spinal Cord Compression* / diagnosis
Spinal Cord Compression* / etiology
Spinal Cord Compression* / therapy