Maternal Hematologic Neoplasms during Pregnancy: Histologic Findings in the Placenta

Ashlie E Rubrecht; Robert P Seifert; Archana Shenoy

doi:10.1016/j.placenta.2020.12.010

Maternal Hematologic Neoplasms during Pregnancy: Histologic Findings in the Placenta

Placenta. 2021 Jan 15:104:195-198. doi: 10.1016/j.placenta.2020.12.010. Epub 2020 Dec 24.

Authors

Ashlie E Rubrecht¹, Robert P Seifert¹, Archana Shenoy²

Affiliations

¹ University of Florida, Department of Pathology, Immunology, and Laboratory Medicine, Gainesville, FL, USA.
² University of Florida, Department of Pathology, Immunology, and Laboratory Medicine, Gainesville, FL, USA; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital and the Ohio State University of College of Medicine, Columbus, OH, USA. Electronic address: shenoy.a@outlook.com.

PMID: 33387877
DOI: 10.1016/j.placenta.2020.12.010

Abstract

Placental metastasis of maternal neoplasms is well documented in solid tumors, unlike hematologic neoplasms. We reviewed placental findings from deliveries complicated by maternal hematologic neoplasms exploring the prevalence and patterns of placental transmission and insufficiency. In the 8-yr study period, 11 cases were analyzed. Acute myeloid leukemia was the most common diagnosis (4/11, 36%). Seven cases (63%) showed no evidence of placental spread of neoplasm, while four cases (36%) showed placental spread, restricted to the maternal compartment. Maternal vascular malperfusion was documented in 8/11 (72%) cases. Neonatal follow up was available in 10 cases, all children were alive and well.

Keywords: Leukemia; Lymphoma; Placenta; Vertical transmission.

MeSH terms

Adult
Female
Hematologic Neoplasms / pathology*
Humans
Placenta / pathology*
Pregnancy
Pregnancy Complications, Hematologic / pathology*
Pregnancy Complications, Neoplastic / pathology*
Pregnancy Outcome