Fanconi's anaemia: correlation of genetic complementation group with psoralen/UVA response

Hum Genet. 1988 Jan;78(1):51-4. doi: 10.1007/BF00291234.

Abstract

The correlation found by Moustacchi (1987) between cellular response to a crosslinking challenge and genetic heterogeneity in Fanconi's anaemia is confirmed for an earlier set of complementation groups (Zakrzewski and Sperling 1980). This allows the matching of the two independently established complementation groupings and better characterization of their DNA repair-related biochemical properties.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia, Aplastic / genetics*
  • Cell Line
  • DNA Repair*
  • Fanconi Anemia / genetics*
  • Genetic Complementation Test*
  • Humans
  • Methoxsalen / pharmacology*
  • Ultraviolet Rays*

Substances

  • Methoxsalen