HPV vaccination introduction worldwide and WHO and UNICEF estimates of national HPV immunization coverage 2010-2019

Prev Med. 2021 Mar;144:106399. doi: 10.1016/j.ypmed.2020.106399. Epub 2020 Dec 31.


WHO/UNICEF estimates for HPV vaccination coverage from 2010 to 2019 are analyzed against the backdrop of the 90% coverage target for HPV vaccination by 2030 set in the recently approved global strategy for cervical cancer elimination as a public health problem. As of June 2020, 107 (55%) of the 194 WHO Member States have introduced HPV vaccination. The Americas and Europe are by far the WHO regions with the most introductions, 85% and 77% of their countries having already introduced respectively. A record number of introductions was observed in 2019, most of which in low- and middle- income countries (LMIC) where access has been limited. Programs had an average performance coverage of around 67% for the first dose and 53% for the final dose of HPV. LMICs performed on average better than high- income countries for the first dose, but worse for the last dose due to higher dropout. Only 5 (6%) countries achieved coverages with the final dose of more than 90%, 22 countries (21%) achieved coverages of 75% or higher while 35 (40%) had a final dose coverage of 50% or less. When expressed as world population coverage (i.e., weighted by population size), global coverage of the final HPV dose for 2019 is estimated at 15%. There is a long way to go to meet the 2030 elimination target of 90%. In the post-COVID era attention should be paid to maintain the pace of introductions, specially ensuring the most populous countries introduce, and further improving program performance globally.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19*
  • Europe
  • Female
  • Humans
  • Immunization Programs
  • Papillomavirus Infections* / prevention & control
  • Papillomavirus Vaccines*
  • SARS-CoV-2
  • United Nations
  • Uterine Cervical Neoplasms* / prevention & control
  • Vaccination
  • Vaccination Coverage
  • World Health Organization


  • Papillomavirus Vaccines