RETRACTED: Knockdown EZH2 attenuates cerebral ischemia-reperfusion injury via regulating microRNA-30d-3p methylation and USP22

Brain Res Bull. 2021 Apr:169:25-34. doi: 10.1016/j.brainresbull.2020.12.019. Epub 2020 Dec 31.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief as there are concerns about the reliability of the results. Concerns have been raised about a portion of Figure 5B, ‘DMSO’ group appears to contain image similarities with Figure 4e, ‘Inhibitor NC’ group, published in Yang et al., 2021 doi: 10.1080/15384101.2020.1856498. A portion of Figure 5B, ‘DZNeP+miR-30d-3p antagomir’ group appears to contain image similarities with Figure 4e, ‘Inhibitor NC’ group, published in Yang et al., 2021. Figure 7/G western blot bands have the same eyebrow shaped phenotype as many other publications as detailed here (https://pubpeer.com/publications/B26AE47AC0E71E0EF339B40893B2C2).

Keywords: Cerebral ischemia-reperfusion injury; Enhancer of zeste homologue 2; Methylation; MicroRNA-30d-3p; Nerve injury; Oxidative stress; Ubiquitin-specific protease 22.

Publication types

  • Retracted Publication

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Brain / metabolism
  • DNA Methylation
  • Enhancer of Zeste Homolog 2 Protein / genetics
  • Enhancer of Zeste Homolog 2 Protein / metabolism*
  • Male
  • Mice
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Motor Activity / physiology
  • Neurons / metabolism*
  • Oxidative Stress / physiology
  • Reperfusion Injury / genetics
  • Reperfusion Injury / metabolism*
  • Ubiquitin Thiolesterase / genetics
  • Ubiquitin Thiolesterase / metabolism*

Substances

  • MicroRNAs
  • Enhancer of Zeste Homolog 2 Protein
  • Ezh2 protein, mouse
  • USP22 protein, mouse
  • Ubiquitin Thiolesterase