Insight Into Inflammasome Signaling: Implications for Toxoplasma gondii Infection

Front Immunol. 2020 Dec 16:11:583193. doi: 10.3389/fimmu.2020.583193. eCollection 2020.

Abstract

Inflammasomes are multimeric protein complexes regulating the innate immune response to invading pathogens or stress stimuli. Recent studies have reported that nucleotide-binding leucine-rich repeat-containing (NLRs) proteins and DNA sensor absent in melanoma 2 (AIM2) serve as inflammasome sentinels, whose stimulation leads to the proteolytic activation of caspase-1, proinflammatory cytokine secretion, and pyroptotic cell death. Toxoplasma gondii, an obligate intracellular parasite of phylum Apicomplexans, is reportedly involved in NLRP1, NLRP3 and AIM2 inflammasomes activation; however, mechanistic evidence regarding the activation of these complexes is preliminary. This review describes the current understanding of inflammasome signaling in rodent and human models of T. gondii infection.

Keywords: AIM2; NLRP1; NLRP3; Toxoplasma gondii; infection; inflammasome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Systematic Review

MeSH terms

  • Animals
  • Humans
  • Inflammasomes / immunology*
  • Toxoplasma / immunology
  • Toxoplasmosis / immunology*

Substances

  • Inflammasomes