Translation of a Host Blood RNA Signature Distinguishing Bacterial From Viral Infection Into a Platform Suitable for Development as a Point-of-Care Test

JAMA Pediatr. 2021 Apr 1;175(4):417-419. doi: 10.1001/jamapediatrics.2020.5227.

Abstract

This study assesses a 2-gene RNA signature that can be translated into a rapid (<25 minutes) and portable laboratory-on-a-chip platform suitable for development as a point-of-care test.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Infections / blood
  • Bacterial Infections / diagnosis*
  • Biomarkers / blood
  • Child
  • Diagnosis, Differential
  • Humans
  • Oligonucleotide Array Sequence Analysis
  • Point-of-Care Testing*
  • RNA / blood*
  • Receptors, Virus / genetics*
  • Sensitivity and Specificity
  • Tumor Suppressor Proteins / genetics*
  • Virus Diseases / blood
  • Virus Diseases / diagnosis*

Substances

  • Biomarkers
  • IFI44L protein, human
  • Receptors, Virus
  • Tumor Suppressor Proteins
  • RNA