Treatment of dural sinus thrombosis with local urokinase infusion. Case report

J Neurosurg. 1988 Feb;68(2):284-7. doi: 10.3171/jns.1988.68.2.0284.


Current therapy for dural sinus thrombosis consists of supportive measures, anticoagulation therapy, and in some cases intravenous infusion of a fibrinolytic agent. A patient with extensive dural sinus thrombosis was successfully treated with local urokinase infusion. The technique and rationale for this aggressive therapy are discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cranial Sinuses*
  • Dura Mater / blood supply
  • Humans
  • Infusions, Intravenous
  • Male
  • Thrombosis / drug therapy*
  • Thrombosis / surgery
  • Urokinase-Type Plasminogen Activator / administration & dosage
  • Urokinase-Type Plasminogen Activator / therapeutic use*


  • Urokinase-Type Plasminogen Activator