The St George's Classification Algorithm of Primary Lymphatic Anomalies

Lymphat Res Biol. 2021 Feb;19(1):25-30. doi: 10.1089/lrb.2020.0104. Epub 2021 Jan 4.


Clinicians and scientists at St George's University Hospital have collaborated to develop a classification algorithm for primary lymphatic anomalies. Instruction is offered on how to apply the algorithm in clinical practice to refine the diagnosis of primary lymphedema and guide on genetic testing and management. It can also be used to interpret mutation testing results of uncertain significance. The algorithm has evolved as more genes have been discovered, and it remains a "work in progress" as further discoveries are made. This transformational approach has revolutionized the understanding and classification of primary lymphatic anomalies.

Keywords: classification algorithm; primary lymphatic anomalies; primary lymphedema.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Humans
  • Lymphatic Abnormalities*
  • Lymphedema*