Eight Days of Water-Only Fasting Promotes Favorable Changes in the Functioning of the Urogenital System of Middle-Aged Healthy Men

Nutrients. 2020 Dec 30;13(1):113. doi: 10.3390/nu13010113.


The aim of this study was to determine whether, after 8 days of water-only fasting, there are changes in the efficiency of the lower urinary tract, the concentration of sex hormones, and the symptoms of prostate diseases in a group of middle-aged men (n = 14). For this purpose, before and after 8 days of water-only fasting (subjects drank ad libitum moderately mineralized water), and the following somatic and blood concentration measurements were made: total prostate specific antigen (PSA-T), free prostate specific antigen (PSA-F), follicle stimulating hormone (FSH), luteotropic hormone (LH), prolactin (Pr), total testosterone (T-T), free testosterone (T-F), dehydroepiandrosterone (DHEA), sex hormone globulin binding (SHGB), total cholesterol (Ch-T), β-hydroxybutyrate (β-HB). In addition, prostate volume (PV), volume of each testis (TV), total volume of both testes (TTV), maximal urinary flow rate (Qmax), and International Prostate Symptom Score (IPSS) values were determined. The results showed that after 8 days of water-only fasting, Qmax and IPSS improved but PV and TTV decreased significantly. There was also a decrease in blood levels of PSA-T, FSH, P, T-T, T-F, and DHEA, but SHGB concentration increased significantly. These results indicate that 8 days of water-only fasting improved lower urinary tract functions without negative health effects.

Keywords: fasting; lower urinary tract; men; sex hormones.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Cholesterol / blood
  • Fasting*
  • Gonadal Steroid Hormones / blood
  • Humans
  • Hydroxybutyrates / blood
  • Male
  • Middle Aged
  • Mineral Waters / administration & dosage*
  • Organ Size
  • Prostatic Diseases / blood
  • Prostatic Diseases / pathology
  • Prostatic Diseases / physiopathology
  • Prostatic Diseases / therapy
  • Sex Hormone-Binding Globulin / metabolism
  • Testis* / pathology
  • Testis* / physiopathology
  • Urinary Tract* / pathology
  • Urinary Tract* / physiopathology


  • Gonadal Steroid Hormones
  • Hydroxybutyrates
  • Mineral Waters
  • SHBG protein, human
  • Sex Hormone-Binding Globulin
  • Cholesterol