Ejaculatory failure and urinary dysfunction secondary to labetalol

J Urol. 1988 Feb;139(2):371-2. doi: 10.1016/s0022-5347(17)42420-7.


We describe 3 men with moderate to severe essential hypertension in whom ejaculatory failure developed after therapy with labetalol, an antihypertensive drug with alpha-1 and beta-adrenergic blocking properties. No decrease in libido or erectile dysfunction was reported by any of the patients. Previous and subsequent antihypertensive therapy with either alpha or beta-adrenergic blocking agents failed to cause similar symptoms. These findings reveal a unique spectrum of genitourinary dysfunction associated with the multireceptor blocking properties of labetalol.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Ejaculation / drug effects*
  • Humans
  • Labetalol / adverse effects*
  • Male
  • Middle Aged
  • Urination Disorders / chemically induced*


  • Labetalol