A Tissue-Specific Endothelial Cell Molecule Involved in Lymphocyte Homing

Nature. 1988 Jan 7;331(6151):41-6. doi: 10.1038/331041a0.

Abstract

An endothelial cell surface molecule that is selectively expressed in mucosal organs is required for lymphocyte homing to mucosal lymphoid tissues. This 'vascular addressin' appears to function as a tissue-specific marker or address signal for recognition by lymphocytes circulating in the blood.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology
  • Antigens, Surface
  • Cadherins
  • Cell Adhesion
  • Cell Adhesion Molecules*
  • Cell Movement*
  • Endothelium, Vascular / analysis*
  • Endothelium, Vascular / immunology
  • Lymph Nodes / metabolism
  • Lymphocytes / physiology*
  • Membrane Glycoproteins / immunology
  • Membrane Glycoproteins / physiology*
  • Mice
  • Mice, Inbred BALB C
  • Organ Specificity
  • Peyer's Patches / metabolism

Substances

  • Antibodies, Monoclonal
  • Antigens, Surface
  • Cadherins
  • Cdh2 protein, mouse
  • Cell Adhesion Molecules
  • Membrane Glycoproteins