On the Role of Central Type-1 Cannabinoid Receptor Gene Regulation in Food Intake and Eating Behaviors

Int J Mol Sci. 2021 Jan 1;22(1):398. doi: 10.3390/ijms22010398.


Different neuromodulatory systems are involved in long-term energy balance and body weight and, among these, evidence shows that the endocannabinoid system, in particular the activation of type-1 cannabinoid receptor, plays a key role. We here review current literature focusing on the role of the gene encoding type-1 cannabinoid receptors in the CNS and on the modulation of its expression by food intake and specific eating behaviors. We point out the importance to further investigate how environmental cues might have a role in the development of obesity as well as eating disorders through the transcriptional regulation of this gene in order to prevent or to treat these pathologies.

Keywords: eating behaviors; food intake; transcriptional regulation; type-1 cannabinoid receptor gene.

Publication types

  • Review

MeSH terms

  • Animals
  • Feeding Behavior*
  • Gene Expression Regulation*
  • Humans
  • Mice
  • Promoter Regions, Genetic
  • Rats
  • Receptor, Cannabinoid, CB1 / genetics*
  • Transcription, Genetic


  • CNR1 protein, human
  • CNR1 protein, mouse
  • Cnr1 protein, rat
  • Receptor, Cannabinoid, CB1