Temporal pattern of alcohol dehydrogenase gene transcription reproduced by Drosophila stage-specific embryonic extracts

Nature. 1988 Feb 4;331(6155):410-5. doi: 10.1038/331410a0.


Regulation of transcription during development has been analysed in vitro using extracts derived from Drosophila embryos. Transcription of mutant templates reveals cis-control regions of the alcohol dehydrogenase promoter responsible for temporal regulation. The activity of a trans-acting protein correlates with the profile of alcohol dehydrogenase expression during embryogenesis.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alcohol Dehydrogenase / genetics*
  • Animals
  • Base Sequence
  • Drosophila / embryology
  • Drosophila / genetics
  • Gene Expression Regulation*
  • Promoter Regions, Genetic
  • Transcription, Genetic*


  • Alcohol Dehydrogenase