Dosimetric Comparison Between Carbon-ion Radiotherapy and Photon Radiotherapy for Stage I Esophageal Cancer

Yosuke Takakusagi; Daisaku Yoshida; Yohsuke Kusano; Kio Kano; Wataru Anno; Keisuke Tsuchida; Nobutaka Mizoguchi; Itsuko Serizawa; Hiroyuki Katoh; Koh Imura; Yoshiki Takayama; Shinichi Minohara; Tadashi Kamada

doi:10.21873/invivo.12277

Dosimetric Comparison Between Carbon-ion Radiotherapy and Photon Radiotherapy for Stage I Esophageal Cancer

In Vivo. 2021 Jan-Feb;35(1):447-452. doi: 10.21873/invivo.12277.

Affiliations

¹ Department of Radiation Oncology, Kanagawa Cancer Center, Yokohama, Japan; y-takakusagi@kcch.jp.
² Department of Radiation Oncology, Kanagawa Cancer Center, Yokohama, Japan.
³ Section of Medical Physics and Engineering, Kanagawa Cancer Center, Yokohama, Japan.

Abstract

Background/aim: The present study aimed to compare the radiation dose distribution of carbon-ion radiotherapy (CIRT) for stage I esophageal cancer with three-dimensional conformal radiotherapy (3DCRT) and volumetric modulated arc therapy (VMAT).

Patients and methods: Fifteen patients with cT1bN0M0 esophageal cancer who received 3DCRT at Kanagawa Cancer Center between January 2014 and April 2019 were enrolled. The dose-volume histogram parameters of the target volume and normal organs planned with CIRT, 3DCRT, and VMAT were evaluated.

Results: The homogeneity index for the target volume of CIRT was significantly lower than that of 3DCRT and VMAT. In addition, the radiation dose of CIRT to the heart, lungs, spinal cord, and skin was significantly lower than that of 3DCRT and VMAT.

Conclusion: Favorable dose distributions with CIRT were demonstrated compared with 3DCRT and VMAT for esophageal cancer.

Keywords: Carbon-ion radiotherapy; dosimetric comparison; esophageal cancer.

MeSH terms

Carbon
Esophageal Neoplasms* / radiotherapy
Humans
Organs at Risk
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Intensity-Modulated*

Substances

Carbon