Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants

N Engl J Med. 2021 Jan 7;384(1):42-50. doi: 10.1056/NEJMoa2030391.

Abstract

Two cases of pediatric lung cancer (in 23-month-old and 6-year-old boys) resulting from mother-to-infant transmission of uterine cervical tumors were incidentally detected during routine next-generation sequencing of paired samples of tumor and normal tissue. Spontaneous regression of some lesions in the first child and slow growth of the tumor mass in the second child suggested the existence of alloimmune responses against the transmitted tumors. Immune checkpoint inhibitor therapy with nivolumab led to a strong regression of all remaining tumors in the first child. (Funded by the Japan Agency for Medical Research and Development and others; TOP-GEAR UMIN Clinical Trials Registry number, UMIN000011141.).

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma, Mucinous / diagnostic imaging
  • Adenocarcinoma, Mucinous / etiology*
  • Adenocarcinoma, Mucinous / genetics
  • Adult
  • Carcinoma, Neuroendocrine / diagnostic imaging
  • Carcinoma, Neuroendocrine / etiology*
  • Carcinoma, Neuroendocrine / genetics
  • Carcinoma, Squamous Cell / pathology
  • Child
  • Exome Sequencing
  • Fatal Outcome
  • Female
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Infant
  • Lung / diagnostic imaging
  • Lung / pathology
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / etiology*
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology
  • Male
  • Mothers
  • Pregnancy
  • Pregnancy Complications, Neoplastic*
  • Uterine Cervical Neoplasms*
  • Vagina