Current Knowledge on Microviridin from Cyanobacteria

Mar Drugs. 2021 Jan 4;19(1):17. doi: 10.3390/md19010017.


Cyanobacteria are a rich source of secondary metabolites with a vast biotechnological potential. These compounds have intrigued the scientific community due their uniqueness and diversity, which is guaranteed by a rich enzymatic apparatus. The ribosomally synthesized and post-translationally modified peptides (RiPPs) are among the most promising metabolite groups derived from cyanobacteria. They are interested in numerous biological and ecological processes, many of which are entirely unknown. Microviridins are among the most recognized class of ribosomal peptides formed by cyanobacteria. These oligopeptides are potent inhibitors of protease; thus, they can be used for drug development and the control of mosquitoes. They also play a key ecological role in the defense of cyanobacteria against microcrustaceans. The purpose of this review is to systematically identify the key characteristics of microviridins, including its chemical structure and biosynthesis, as well as its biotechnological and ecological significance.

Keywords: biotechnology; cyanobacteria; ecology; microviridin; oligopeptide.

Publication types

  • Review

MeSH terms

  • Animals
  • Cyanobacteria / chemistry*
  • Ecology
  • Humans
  • Insect Control
  • Oligopeptides / chemistry
  • Oligopeptides / pharmacology
  • Protease Inhibitors / pharmacology


  • Oligopeptides
  • Protease Inhibitors