Ruptured blood blister like aneurysm: does the best therapeutic option really exist?

Neurosurg Rev. 2021 Oct;44(5):2767-2775. doi: 10.1007/s10143-020-01463-4. Epub 2021 Jan 7.


Our study aimed to evaluate the outcome of patients with ruptured blood-blister like aneurysm (BBLA) in our institution by comparing microsurgical selective treatment to endovascular treatment using flow-diverter stent (FD). Our study included 18 consecutive patients treated for BBLA between 2004 and 2020. Until 2014, microsurgery was preferred in all patients with BBLA (n = 10). Significant postoperative morbi-mortality was recorded at this time and led us to change therapeutic strategy and to favor FD as first-line treatment in all patients (n = 8). Postprocedural complications and BBLA occlusion were recorded. High WFNS score (> 2) was noted in 6 patients of microsurgical group and in 2 of endovascular group. In microsurgical group, ischemic lesions were noted in 6 patients and led to death in 3 patients. Immediate BBLA occlusion was obtained in all patients. Favorable outcome after 3 months (mRS < 3) was recorded in 4 of the 7 survivors. In endovascular group, ischemic lesions were noted in 4 patients. One patient died from early postprocedural BBLA rebleeding. Scarpa hematoma was noted in 3 patients with surgical evacuation in 1. Persistent BBLA at 3 months was recorded in 4 patients without rebleeding, but further FD was required in 1 with growing BBLA. Favorable outcome was noted in 6 of the 7 survivors. Although, rate of morbi-mortality appear lower in patients treated with FD, neurological presentation was better and BBLA diagnosis remains questionable in this group. Moreover, persistent BBLA imaging with potential risk of rebleeding after FD deserves to be discussed.

Keywords: Blister aneurysm; Bypass; Encircling graft clip; Flow-diverter; Subarachnoid hemorrhage.

MeSH terms

  • Aneurysm, Ruptured* / surgery
  • Embolization, Therapeutic*
  • Endovascular Procedures*
  • Humans
  • Intracranial Aneurysm* / surgery
  • Retrospective Studies
  • Subarachnoid Hemorrhage* / surgery
  • Treatment Outcome