A case of eosinophilic esophagitis with autoimmune polyendocrine syndrome type 2, including autoimmune gastritis

Clin J Gastroenterol. 2021 Apr;14(2):460-465. doi: 10.1007/s12328-020-01333-y. Epub 2021 Jan 7.

Abstract

Both eosinophilic esophagitis (EoE) and autoimmune polyendocrine syndrome (APS) are relatively rare diseases in Japan. We herein report a case of EoE with APS in a 67-year-old Japanese man who presented with chest pain and dysphagia. On the basis of endoscopic findings and histological analysis, we diagnosed the patient with EoE along with autoimmune gastritis. Additional serological examinations revealed the presence of Hashimoto's thyroiditis and type 1 diabetes, which led to the final diagnosis of APS. His symptoms did not respond to treatment with a proton-pump inhibitor but improved with topical steroid therapy. This case of coexisting EoE and APS-2 is quite rare and has several implications for the pathogenesis of both conditions.

Keywords: Autoimmune gastritis; Autoimmune polyendocrine syndrome; Eosinophilic esophagitis; Regulatory T cells.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Diabetes Mellitus, Type 2*
  • Eosinophilic Esophagitis* / complications
  • Eosinophilic Esophagitis* / diagnosis
  • Eosinophilic Esophagitis* / drug therapy
  • Gastritis* / complications
  • Gastritis* / diagnosis
  • Gastritis* / drug therapy
  • Humans
  • Japan
  • Male
  • Polyendocrinopathies, Autoimmune* / complications
  • Polyendocrinopathies, Autoimmune* / diagnosis
  • Polyendocrinopathies, Autoimmune* / drug therapy
  • Proton Pump Inhibitors / therapeutic use

Substances

  • Proton Pump Inhibitors