Radiosynthesis of 18F-fluoroethylated tracers via a simplified one-pot 18F-fluoroethylation method using [18F]fluoroethyl tosylate

Appl Radiat Isot. 2021 Mar:169:109571. doi: 10.1016/j.apradiso.2020.109571. Epub 2020 Dec 26.


Recently, a straightforward one-pot method for 18F-fluoroethylation without azeotropic drying of cyclotron-produced [18F]F- was developed. In this study, we have attempted to simplify the automated radiosynthesis of two [18F]fluoroethylated tracers, [18F]FEDAC and [18F]FET, using a desmethyl labeling precursor and [18F]fluoroethyl tosylate, based on the above-mentioned method. The radiochemical yields of [18F]FEDAC and [18F]FET were 26 ± 3.7% (n = 5) and 14 ± 2.2% (n = 4), respectively, based on total [18F]F- at the end of irradiation.

Keywords: (18)F-fluoroethylation; One-pot; [(18)F]FEDAC; [(18)F]FET; [(18)F]fluoroethyl tosylate.