Electroretinograms in autism: a pilot study of b-wave amplitudes

Am J Psychiatry. 1988 Feb;145(2):229-32. doi: 10.1176/ajp.145.2.229.


The authors recorded electroretinograms for 27 autistic patients and 20 age- and sex-matched healthy volunteers. Thirteen (48%) of the autistic patients demonstrated subnormal b-wave amplitudes, which may indicate abnormal retinal function. One patient was tested serially at two sites; his low b-wave amplitude did not vary over time or between the two sites. If this retinal finding can be confirmed at other laboratories and in larger samples of autistic patients, it might provide a marker for a specific subtype of autism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Autistic Disorder / physiopathology*
  • Child
  • Electroretinography*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pilot Projects
  • Retina / physiopathology*
  • Sex Factors