Unlocking Tissue Regenerative Potential by Epigenetic Reprogramming

Pradeep Reddy; Sebastian Memczak; Juan Carlos Izpisua Belmonte

doi:10.1016/j.stem.2020.12.006

Unlocking Tissue Regenerative Potential by Epigenetic Reprogramming

Cell Stem Cell. 2021 Jan 7;28(1):5-7. doi: 10.1016/j.stem.2020.12.006.

Authors

Pradeep Reddy¹, Sebastian Memczak¹, Juan Carlos Izpisua Belmonte²

Affiliations

¹ The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
² The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: belmonte@salk.edu.

PMID: 33417872
DOI: 10.1016/j.stem.2020.12.006

Abstract

The regeneration potential of axons projecting from retinal ganglion cells (RGCs) is lost shortly after birth. In Nature, Lu et al. (2020) demonstrate that epigenetic reprogramming of RGCs by overexpression of Oct4, Sox2, and Klf4 leads to axon regeneration and restoration of vision in a glaucoma model and aged mice.

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MeSH terms

Animals
Axons*
Epigenesis, Genetic
Kruppel-Like Factor 4
Mice
Nerve Regeneration*
Retinal Ganglion Cells
Vision, Ocular