[A case of bronchial carcinoma showing regression upon intratumoral administration of OK-432]

Gan To Kagaku Ryoho. 1988 Feb;15(2):341-4.
[Article in Japanese]


A 38-year-old female suffering from chronic respiratory symptoms due to lung cancer occupying the left main bronchus was treated by frequent intratumoral injections of OK-432. The immune-modifying therapy was performed as follows; 0.2 KE of OK-432 was injected intracutaneously once a week, then the dose was gradually increased to 3.0 KE once a week. Following immunization, intratumoral injection was done under endoscopy at a dose of 3.0 KE every two weeks. Three months later, the tumor showed remarkable regression, and clinical symptoms were diminished. In conclusion, intratumoral injection of OK-432 was considered to be very beneficial in lung cancer.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Biological Products / administration & dosage*
  • Bronchial Neoplasms / therapy*
  • Bronchoscopy
  • Carcinoma, Squamous Cell / therapy*
  • Female
  • Humans
  • Picibanil / administration & dosage*
  • Picibanil / therapeutic use
  • Remission Induction


  • Biological Products
  • Picibanil