RETRACTED: Exosomal miR-22-3p from human umbilical cord blood-derived mesenchymal stem cells protects against lipopolysaccharid-induced acute lung injury

Life Sci. 2021 Mar 15:269:119004. doi: 10.1016/j.lfs.2020.119004. Epub 2021 Jan 6.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Concern was raised about the reliability of the Western blot results in Figs. 2D/H/L, and 7B/F, which appear to have the same eyebrow shaped phenotype as many other publications tabulated here (https://docs.google.com/spreadsheets/d/149EjFXVxpwkBXYJOnOHb6RhAqT4a2llhj9LM60MBffM/edit#gid=0). Concerns were also raised over the provenance of the flow cytometry plots in Fig. 1C. The journal requested the corresponding author comment on these concerns and provide the raw data. However the authors were not able to satisfactorily fulfil this request and therefore the Editor-in-Chief decided to retract the article.

Keywords: Acute lung injury; Apoptosis; Exosomes; Frizzled class receptor 6; Human umbilical cord blood-derived mesenchymal stem cells; MicroRNA-22-3p; Proliferation.

Publication types

  • Retracted Publication

MeSH terms

  • Acute Lung Injury / chemically induced
  • Acute Lung Injury / pathology*
  • Adult
  • Animals
  • Apoptosis
  • Base Sequence
  • Cell Line
  • Cell Proliferation
  • Disease Models, Animal
  • Disease Progression
  • Exosomes / metabolism*
  • Fetal Blood / cytology*
  • Frizzled Receptors / metabolism
  • Gene Silencing
  • Humans
  • Inflammation / pathology
  • Lipopolysaccharides
  • Male
  • Mesenchymal Stem Cells / metabolism*
  • MicroRNAs / metabolism*
  • Oxidative Stress
  • Protective Agents / metabolism*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • FZD6 protein, human
  • Frizzled Receptors
  • Lipopolysaccharides
  • MIRN22 microRNA, human
  • MicroRNAs
  • Protective Agents