Treatment of benzodiazepine withdrawal syndrome in a severe traumatic brain injury patient

BMJ Case Rep. 2021 Jan 8;14(1):e238318. doi: 10.1136/bcr-2020-238318.

Abstract

Prolonged exposure to benzodiazepines (BDZ) may contribute towards physical dependence, which is manifested by iatrogenic Benzodiazepine Withdrawal Syndrome (BWS), a condition often underdiagnosed. Current evidence recommends precluding BDZ infusion as sedation in the intensive care unit to avoid possible withdrawal and delirium issues. Administration of dexmedetomidine should be considered to facilitate weaning in patients with BWS.

Keywords: adult intensive care; intensive care; mechanical ventilation.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Brain Injuries, Traumatic / therapy*
  • Humans
  • Hypnotics and Sedatives / administration & dosage
  • Hypnotics and Sedatives / adverse effects*
  • Male
  • Midazolam / administration & dosage
  • Midazolam / adverse effects*
  • Substance Withdrawal Syndrome / diagnosis*
  • Substance Withdrawal Syndrome / etiology*
  • Substance Withdrawal Syndrome / therapy

Substances

  • Hypnotics and Sedatives
  • Midazolam