Pathogenicity comparison of the SMPV-11 and attenuated mink enteritis virus F61 in mink

Yang Wang; Bo Hu; Rongguang Lu; Fanshu Ma; Shuang Lv; Hailing Zhang; Xue Bai; Lei Zhang; Ning Shi; Xintong Li; Sining Fan; Shizhen Lian; Xijun Yan; Yanzhu Zhu

doi:10.1016/j.virusres.2021.198294

Pathogenicity comparison of the SMPV-11 and attenuated mink enteritis virus F61 in mink

Virus Res. 2021 Mar:294:198294. doi: 10.1016/j.virusres.2021.198294. Epub 2021 Jan 7.

Authors

Yang Wang¹, Bo Hu², Rongguang Lu², Fanshu Ma³, Shuang Lv², Hailing Zhang², Xue Bai², Lei Zhang², Ning Shi³, Xintong Li⁴, Sining Fan⁵, Shizhen Lian², Xijun Yan⁶, Yanzhu Zhu⁷

Affiliations

¹ Key Laboratory of Special Animal Epidemic Disease, Ministry of Agriculture, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China; Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
² Key Laboratory of Special Animal Epidemic Disease, Ministry of Agriculture, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
³ Key Laboratory of Special Animal Epidemic Disease, Ministry of Agriculture, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China; College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China.
⁴ Key Laboratory of Special Animal Epidemic Disease, Ministry of Agriculture, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China; State Key Laboratory of Membrane Biology, Institute of Zoology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100101, China.
⁵ Key Laboratory of Special Animal Epidemic Disease, Ministry of Agriculture, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China; Shenyang Huibai Biotechnology Co., Ltd, Shenyang 110003 China.
⁶ Key Laboratory of Special Animal Epidemic Disease, Ministry of Agriculture, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China; Sinovet Biopharm. Co., Ltd., Taizhou 100085, China. Electronic address: yanxijungmp@163.com.
⁷ Key Laboratory of Special Animal Epidemic Disease, Ministry of Agriculture, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China. Electronic address: zyzzu@126.com.

PMID: 33422556
DOI: 10.1016/j.virusres.2021.198294

Abstract

Mink enteritis virus (MEV) is a major pathogen inducing acute hemorrhagic enteritis in mink. This study aims to determine the pathogenicity of the isolated MEV strain (SMPV-11) compared with the attenuated MEV strain (MEV-F61) in the mink. The two MEV strains were inoculated in the two mink groups, respectively. Then the clinical symptom, hematological, serological, and histopathological change were evaluated. Our findings showed that there were differences in the clinical features and pathological changes of the SMPV-11 and MEV-F61 in the mink. It indicates that SMPV-11 is a virulent strain, and it can be the potential MEV vaccine strain in the mink.

Keywords: Attenuated strain; Clinical feature; Mink enteritis virus; Virulent strain.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Mink
Mink enteritis virus* / genetics
Virulence