Soluble DC-SIGN isoforms: Ligands with unknown functions - A mini-review

Microb Pathog. 2021 Jan:150:104731. doi: 10.1016/j.micpath.2021.104731. Epub 2021 Jan 8.

Abstract

The present study aimed to perform a mini-review of the complete soluble isoforms of Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (sDC-SIGN), their functions, and their correlation with diseases. The present review reveals the lack of studies regarding these soluble isoforms and poor understanding of the importance of the topic, considering the concordant findings on the relevant influence of sDC-SIGN in the viral and bacterial infection process, in addition to its possible use as a cancer marker.

Keywords: DC-SIGN; Functions; Isoforms; sDC-SIGN.

Publication types

  • Review

MeSH terms

  • Cell Adhesion Molecules
  • Dendritic Cells*
  • Lectins, C-Type* / genetics
  • Ligands
  • Protein Isoforms / genetics
  • Receptors, Cell Surface

Substances

  • Cell Adhesion Molecules
  • DC-specific ICAM-3 grabbing nonintegrin
  • Lectins, C-Type
  • Ligands
  • Protein Isoforms
  • Receptors, Cell Surface