[Cardiovascular disorders in autosomal dominant polycystic kidney disease]

Abstract

Autosomal dominant polycystic kidney disease is the most frequent genetic kidney disease. Cardiovascular disorders associated with autosomal dominant polycystic kidney disease are multiple and may occur early in life. In autosomal dominant polycystic kidney disease cardiovascular morbidity and mortality are related both to the nonspecific consequences of chronic kidney disease and to the particular phenotype of autosomal dominant polycystic kidney disease. Compared to the general population, patients with autosomal dominant polycystic kidney disease present an increased prevalence of hypertension, left ventricular hypertrophy, atrial fibrillation, valvular diseases, aneurisms and arterial dissections. This review article provides an update on cardiovascular disorders associated with autosomal dominant polycystic kidney disease and recent pathophysiological developments.

Keywords: Anévrisme artériel; Arterial aneurism; Arterial hypertension; Autosomal dominant polycystic kidney disease; Cardiomyopathie; Cardiomyopathy; Dysfonction endothéliale; Endothelial dysfunction; Hypertension artérielle; Polykystose rénale autosomique dominante.