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Review
. 2021 Feb;3(2):142-148.
doi: 10.1038/s42255-020-00327-x. Epub 2021 Jan 11.

Metabolic Messengers: glucagon-like peptide 1

Fiona M Gribble  1 , Frank Reimann  2
Affiliations
Review

Metabolic Messengers: glucagon-like peptide 1

Fiona M Gribble et al. Nat Metab. 2021 Feb.

Abstract

Glucagon like peptide-1 (GLP-1), a peptide hormone from the intestinal tract, plays a central role in the coordination of postprandial glucose homeostasis through actions on insulin secretion, food intake and gut motility. GLP-1 forms the basis for a variety of current drugs for the treatment of type 2 diabetes and obesity, as well as new agents currently being developed. Here, we provide a concise overview of the core physiology of GLP-1 secretion and action, and the role of the peptide in human health, disease and therapeutics.

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