The global pandemic COVID-19 culminated in escalating biomedical waste (BMW) worldwide, and the management authorities are struggling with waste treatment. Bangladesh and India are two densely populated South Asian developing countries with limited resources. Both countries face mass community transmission of the disease, with India facing severe infections and deaths. Predictably, a large population might sum up to a large amount of COVID-19-related BMW. There is also the question of capacity, whether the existing BMW policies and regulations of the regions can manage the BMW strategically driven by the pressure of the pandemic. Here, we have shown a framework leading to further environmental and community transmission of the COVID-19 pandemic if the BMW generated at healthcare facilities and homes is not appropriately managed. The BMW, such as safety suits or personal protective equipment (PPE), masks, gloves, and shields, would likely damage the environment in the long run by creating microplastic pollution. Modification and modernization of the existing policies, plans, and guidelines on the proper management of the hospital and household infectious waste is suggested. Moreover, occupational health and safety assessments for waste management workers at the hospitals are recommended. Installing suitable capacity incinerators and related infrastructures are recommended for appropriate waste management. In the absence of incinerators, the existing industrial furnaces, cement kilns, and mobile incinerators can be used with a rapid impact assessment adhering to the appropriate implementations of the policies and guidelines.