Stanene-Based Nanosheets for β-Elemene Delivery and Ultrasound-Mediated Combination Cancer Therapy

Angew Chem Int Ed Engl. 2021 Mar 22;60(13):7155-7164. doi: 10.1002/anie.202016330. Epub 2021 Feb 18.

Abstract

Ultrasound (US)-mediated sonodynamic therapy (SDT) has emerged as a superior modality for cancer treatment owing to the non-invasiveness and high tissue-penetrating depth. However, developing biocompatible nanomaterial-based sonosensitizers with efficient SDT capability remains challenging. Here, we employed a liquid-phase exfoliation strategy to obtain a new type of two-dimensional (2D) stanene-based nanosheets (SnNSs) with a band gap of 2.3 eV, which is narrower than those of the most extensively studied nano-sonosensitizers, allowing a more efficient US-triggered separation of electron (e- )-hole (h+ ) pairs for reactive oxygen species (ROS) generation. In addition, we discovered that such SnNSs could also serve as robust near-infrared (NIR)-mediated photothermal therapy (PTT) agents owing to their efficient photothermal conversion, and serve as nanocarriers for anticancer drug delivery owing to the inherent 2D layered structure. This study not only presents general nanoplatforms for SDT-enhanced combination cancer therapy, but also highlights the utility of 2D SnNSs to the field of nanomedicine.

Keywords: combination cancer therapy; photothermal therapy; sonodynamic therapy; stanene; two-dimensional materials.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry*
  • Combined Modality Therapy
  • Drug Carriers / chemistry
  • Drug Delivery Systems*
  • Humans
  • Molecular Structure
  • Nanomedicine
  • Nanoparticles / chemistry*
  • Neoplasms / metabolism
  • Neoplasms / therapy*
  • Particle Size
  • Photothermal Therapy*
  • Reactive Oxygen Species / metabolism
  • Sesquiterpenes / chemistry*
  • Ultrasonic Therapy*
  • Ultrasonic Waves

Substances

  • Biocompatible Materials
  • Drug Carriers
  • Reactive Oxygen Species
  • Sesquiterpenes
  • beta-elemene