Gluing Proteins for Targeted Degradation

Cancer Cell. 2021 Jan 11;39(1):19-21. doi: 10.1016/j.ccell.2020.12.020.


Targeted protein degradation is an emerging technology for drug development. An article published in Nature reported a novel mechanism of targeted protein degradation triggered by small-molecule-induced polymerization of the oncogenic transcription factor BCL6.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adhesives*
  • Humans
  • Oncogenes*
  • Polymerization
  • Proteolysis
  • Proto-Oncogene Proteins c-bcl-6 / metabolism


  • Adhesives
  • BCL6 protein, human
  • Proto-Oncogene Proteins c-bcl-6