Epidemiology and prognostic implications of panic disorder and generalized anxiety disorder in patients with coronary artery disease: rationale and design for a longitudinal cohort study

BMC Cardiovasc Disord. 2021 Jan 12;21(1):26. doi: 10.1186/s12872-021-01848-3.


Background: Anxiety is associated with poorer prognosis in patients with coronary artery disease (CAD). Due to their severity and chronic course, anxiety disorders, particularly generalized anxiety disorder (GAD) and panic disorder (PD), are of considerable interest and clinical importance in this population. This study has two main objectives: (1) to estimate the prevalence and incidence of GAD and PD in patients with CAD over a 2-year period and (2) to prospectively assess the association between PD or GAD and adverse cardiac events, treatment adherence, CAD-related health behaviors, quality of life and psychological distress.

Design/method: This is a longitudinal cohort study in which 3610 participants will be recruited following a CAD-related revascularization procedure. They will complete an interview and questionnaires at 5 time points over a 2-year period (baseline and follow-ups after 3, 6, 12 and 24 months). The presence of PD or GAD, adherence to recommended treatments, health behaviors, quality of life and psychological distress will be assessed at each time point. Data regarding mortality and adverse cardiac events will be collected with a combination of interviews and review of medical files.

Discussion: This study will provide essential information on the prevalence and incidence of anxiety disorders in patients with CAD and on the consequences of these comorbidities. Such data is necessary in order to develop clear clinical recommendations for the management of PD and GAD in patients with CAD. This will help improve the prognosis of patients suffering from both conditions.

Keywords: Adverse cardiac events; Anxiety disorders; Coronary artery disease; Generalized anxiety disorder; Panic disorder; Prognosis; Revascularization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anxiety Disorders / diagnosis
  • Anxiety Disorders / epidemiology*
  • Anxiety Disorders / psychology
  • Anxiety Disorders / therapy
  • Coronary Artery Disease / diagnostic imaging
  • Coronary Artery Disease / epidemiology*
  • Coronary Artery Disease / psychology
  • Coronary Artery Disease / therapy
  • Health Knowledge, Attitudes, Practice
  • Humans
  • Incidence
  • Longitudinal Studies
  • Mental Health
  • Panic Disorder / diagnosis
  • Panic Disorder / epidemiology*
  • Panic Disorder / psychology
  • Panic Disorder / therapy
  • Patient Compliance
  • Prevalence
  • Prognosis
  • Prospective Studies
  • Psychological Distress
  • Quality of Life
  • Quebec / epidemiology
  • Research Design*
  • Time Factors