The effect of polymorphisms (174G> C and 572C> G) on the Interleukin-6 gene in coronary artery disease: a systematic review and meta-analysis

Nader Salari; Kamran Mansouri; Amin Hosseinian-Far; Hooman Ghasemi; Masoud Mohammadi; Rostam Jalali; Aliakbar Vaisi-Raygani

doi:10.1186/s41021-021-00172-8

The effect of polymorphisms (174G> C and 572C> G) on the Interleukin-6 gene in coronary artery disease: a systematic review and meta-analysis

Genes Environ. 2021 Jan 12;43(1):1. doi: 10.1186/s41021-021-00172-8.

Authors

Nader Salari¹, Kamran Mansouri², Amin Hosseinian-Far³, Hooman Ghasemi⁴, Masoud Mohammadi⁵, Rostam Jalali⁶, Aliakbar Vaisi-Raygani⁶

Affiliations

¹ Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
² Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
³ Department of Business Systems & Operations, University of Northampton, Northampton, UK.
⁴ Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
⁵ Department of Nursing, School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran. Masoud.mohammadi1989@yahoo.com.
⁶ Department of Nursing, School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Abstract

Background: Coronary Artery Disease (CAD) is caused by the blockage of the coronary arteries. it is argued that there has an association between the Interleukin-6 gene and the occurrence of atherosclerosis, coronary artery disease, Due to the short half-life and high variability of Interleukin-6 (IL-6), limited studies have been performed on the association of serum levels of interleukin-6 with coronary artery disease. The aim of this study is to investigate the relationship between IL-6 gene polymorphisms and coronary artery disease.

Methods: This study was conducted as a meta-analysis of selected articles with no lower time limit and upto March 2020. Articles related to the subject were obtained by searching several data sources,such as the SID, IranDoc, Scopus, Embase, Web of Science (ISI), PubMed, Science Direct, and Google Scholar databases. The heterogeneity of the studies was assessed using the I² index in the Comprehensive Meta-Analysis software.

Results: The GG genotype of the IL-6174 G> C polymorphism with a 0.8 odds ratio tended to reduce the risk of CAD by 20%. The odds ratio of CAD in CG and GG genotypes were found to be 1.16 and 1.48 times respectively, indicating the increasing effect of these two genotypes. In the IL-6-572 C>G polymorphism, CG and GG genotypes increased the risk of CAD by 1.21 and 1.27 times respectively, and the CC genotype tended to reduce the risk of CAD by 15%, considering the odds ratio of 0.85.

Conclusion: This study showed a relationship between IL-6174G> C and Interleukin-6 (IL-6) 572 C>G genes and coronary artery disease. Moreover, the protective effects of GG genotype in IL-6 gene 174 G> C and CC genotype in IL-6 gene 572 C>G gene were reported. The study also confirmed that the CG and CC genotypes of the G>C IL-6174 gene have an increasing effect on coronary artery disease. Moreover, CG and GG genotypes in the IL-6 gene 572 C>G increased the risk of developing CAD. It should be noted that the increased risk of developing CAD was limited to meta-analytic studies in reported literatures.

Keywords: Atherosclerosis; Cardiovascular disease; Coronary artery disease; IL-6 -572C> G; IL-6174 G> C; Polymorphism.