Illuminating Non-genetic Cellular Heterogeneity with Imaging-Based Spatial Proteomics

Trends Cancer. 2021 Apr;7(4):278-282. doi: 10.1016/j.trecan.2020.12.006. Epub 2021 Jan 10.


Cellular heterogeneity is an important biological phenomenon observed across space and time in human tissues. Imaging-based spatial proteomic technologies can provide fruitful new readouts of phenotypic states for individual cells at subcellular resolution, which may help unravel the roles of non-genetic cellular heterogeneity in tumorigenesis and drug resistance.

Keywords: heterogeneity; localization; proteomics; single cell; spatiotemporal.

Publication types

  • Review

MeSH terms

  • Humans
  • Molecular Imaging
  • Neoplasms / metabolism
  • Proteins / metabolism
  • Proteomics*
  • Single-Cell Analysis


  • Proteins