Impact of COVID-19 on Pregnancy

Int J Med Sci. 2021 Jan 1;18(3):763-767. doi: 10.7150/ijms.49923. eCollection 2021.


Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is an emerging disease. There has been a rapid increase in cases and deaths since it was identified in Wuhan, China, in early December 2019, with over 4,000,000 cases of COVID-19 including at least 250,000 deaths worldwide as of May 2020. However, limited data about the clinical characteristics of pregnant women with COVID-19 have been reported. Given the maternal physiologic and immune function changes during pregnancy, pregnant women may be at a higher risk of being infected with SARS-CoV-2 and developing more complicated clinical events. Information on severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) may provide insights into the effects of COVID-19's during pregnancy. Even though SARS and MERS have been associated with miscarriage, intrauterine death, fetal growth restriction and high case fatality rates, the clinical course of COVID-19 pneumonia in pregnant women has been reported to be similar to that in non-pregnant women. In addition, pregnant women do not appear to be at a higher risk of catching COVID-19 or suffering from more severe disease than other adults of similar age. Moreover, there is currently no evidence that the virus can be transmitted to the fetus during pregnancy or during childbirth. Babies and young children are also known to only experience mild forms of COVID-19. The aims of this systematic review were to summarize the possible symptoms, treatments, and pregnancy outcomes of women infected with COVID-19 during pregnancy.

Keywords: Coronavirus disease 2019 (COVID-19); Pregnancy; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Wuhan pneumonia.

Publication types

  • Systematic Review

MeSH terms

  • Adult
  • COVID-19 / epidemiology*
  • COVID-19 / immunology
  • COVID-19 / therapy
  • COVID-19 / transmission
  • Female
  • Humans
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical*
  • Maternal Exposure
  • Middle East Respiratory Syndrome Coronavirus / immunology
  • Pregnancy
  • Pregnancy Complications, Infectious / epidemiology*
  • Pregnancy Complications, Infectious / immunology
  • Pregnancy Complications, Infectious / therapy
  • Pregnancy Complications, Infectious / virology
  • Pregnancy Outcome*
  • SARS-CoV-2 / immunology*
  • SARS-CoV-2 / isolation & purification
  • Severe Acute Respiratory Syndrome / epidemiology
  • Severe Acute Respiratory Syndrome / immunology
  • Severe Acute Respiratory Syndrome / virology
  • Severe acute respiratory syndrome-related coronavirus / immunology
  • Severity of Illness Index