Are all wines made from various grape varieties beneficial in the prevention of myocardial infarction and stroke?

Masahiro Iwasaki; Masahiro Murakami; Yoshinobu Ijiri; Muneshige Shimizu; Junichiro Yamamoto

doi:10.2144/fsoa-2020-0098

Are all wines made from various grape varieties beneficial in the prevention of myocardial infarction and stroke?

Future Sci OA. 2020 Nov 9;7(2):FSO649. doi: 10.2144/fsoa-2020-0098.

Authors

Masahiro Iwasaki¹, Masahiro Murakami², Yoshinobu Ijiri³, Muneshige Shimizu⁴, Junichiro Yamamoto⁵

Affiliations

¹ Division of Nutrition & Metabolism, Original Nutrition Co., Ltd, Osaka 532-0002, Japan.
² Faculty of Pharmacy, Osaka Ohtani University, Osaka 584-8540, Japan.
³ Department of Health and Nutrition, Osaka Shoin Women's University, Osaka 577-8550, Japan.
⁴ Department of Fisheries, School of Marine Science and Technology, Tokai University, Shizuoka 424-8610, Japan.
⁵ Kobe Gakuin University (Professor Emeritus), Kobe 651-2180, Japan.

Abstract

Aim: Epidemiologic studies support the assumption (French paradox hypothesis) that drinking red wine is beneficial in the prevention of cardiovascular diseases. Our recent works however cast doubt on such claim. Earlier we have shown that the antithrombotic activity of various fruits and vegetables mainly depends on their varieties. For this reason, several varieties of red and white grapes were tested for antithrombotic effect in animal experiments.

Results: Antithrombotic effect of 45 red and white grape varieties were assessed in the present study. Out of the 45, one red grape variety showed antithrombotic effect, while the majority of red and white grape varieties enhanced thrombosis.

Conclusion: Most red and white grape varieties enhanced thrombotic activity of blood.

Keywords: cardiovascular disease; fibrinolysis; grape; platelet aggregation; red wine; shear stress; stroke; thrombosis.