Cobalt Phosphide (Co2P) with Notable Electrocatalytic Activity Designed for Sensitive and Selective Enzymeless Bioanalysis of Hydrogen Peroxide

Donghang Yin; Junyan Tang; Rongbiao Bai; Shuyi Yin; Mengnan Jiang; Zigui Kan; Hongmei Li; Fei Wang; Caolong Li

doi:10.1186/s11671-020-03469-9

Cobalt Phosphide (Co₂P) with Notable Electrocatalytic Activity Designed for Sensitive and Selective Enzymeless Bioanalysis of Hydrogen Peroxide

Nanoscale Res Lett. 2021 Jan 13;16(1):11. doi: 10.1186/s11671-020-03469-9.

Authors

Donghang Yin¹, Junyan Tang¹, Rongbiao Bai¹, Shuyi Yin¹, Mengnan Jiang¹, Zigui Kan¹, Hongmei Li¹, Fei Wang², Caolong Li^{3

4}

Affiliations

¹ Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, 211198, People's Republic of China.
² Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, 211198, People's Republic of China. feiwang@cpu.edu.cn.
³ Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, 211198, People's Republic of China. licl@cpu.edu.cn.
⁴ Tibetan Medicine Research Institute, Tibetan Traditional Medical College, Lhasa, 850000, Tibet, People's Republic of China. licl@cpu.edu.cn.

Abstract

In this work, cobalt phosphide nanoparticles (Co₂P NPs) were prepared by simple and mild hydrothermal method without the use of harmful phosphorous source. The morphological structure and surface component of Co₂P were characterized by transmission electron microscopy, X-ray diffraction and X-ray photoelectron spectroscopy measurements. Considering the excellent electrocatalytic reduction activity and good electrical conductivity of transition-metal phosphide, we fabricated Co₂P NPs on indium tin oxide (ITO) substrate (Co₂P/ITO) for H₂O₂ detection. The Co₂P/ITO transducer displayed a rapid amperometric response less than 5 s, a broader response range from 0.001 to 10.0 mM and a low detection limit of 0.65 μM. In addition, the non-enzymatic Co₂P/ITO sensor showed outstanding selectivity, reproducibility, repeatability and stability, all of which qualified the Co₂P/ITO electrode for quite a reliable and promising biosensor for H₂O₂ sensing.

Keywords: Amperometric sensor; Cobalt phosphide; Hydrogen peroxide; Non-enzymatic.

Abstract

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