Nanophthalmic sclera. Fibronectin studies

Ophthalmology. 1988 Jan;95(1):56-60. doi: 10.1016/s0161-6420(88)33215-x.


The authors performed fibronectin studies on scleral specimens derived from a patient with nanophthalmos. Immunohistochemical staining with antifibronectin was conducted using both formaldehyde-fixed, paraffin-embedded tissue sections and unfixed tissue-cultured scleral cells. In each case, the nanophthalmic samples exhibited fibronectin staining stronger than that obtained from normal human subjects. Results from an enzyme-linked immunosorbent assay (ELISA) confirmed the histologic findings that, in tissue culture, the patient's scleral cells contained and secreted a higher amount of fibronectin than did the normal control cells. The elevated fibronectin level may be related to the development of nanophthalmos.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Enzyme-Linked Immunosorbent Assay
  • Eye Diseases / metabolism*
  • Eye Diseases / pathology
  • Fibroblasts / metabolism
  • Fibronectins / metabolism*
  • Humans
  • Immunohistochemistry
  • Sclera / metabolism
  • Sclera / pathology


  • Fibronectins