The lifecycle of skeletal muscle mitochondria in obesity

doi:10.1111/obr.13164

Review

. 2021 May;22(5):e13164.

doi: 10.1111/obr.13164. Epub 2021 Jan 13.

The lifecycle of skeletal muscle mitochondria in obesity

Chantal A Pileggi^{1

2}, Gaganvir Parmar^{1

2}, Mary-Ellen Harper^{1

2}

Affiliations

¹ Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
² Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.

PMID: 33442950
DOI: 10.1111/obr.13164

Review

The lifecycle of skeletal muscle mitochondria in obesity

Chantal A Pileggi et al. Obes Rev. 2021 May.

. 2021 May;22(5):e13164.

doi: 10.1111/obr.13164. Epub 2021 Jan 13.

Authors

Chantal A Pileggi^{1

2}, Gaganvir Parmar^{1

2}, Mary-Ellen Harper^{1

2}

Affiliations

¹ Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
² Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.

PMID: 33442950
DOI: 10.1111/obr.13164

Abstract

Skeletal muscle possesses dramatic metabolic plasticity that allows for the rapid adaptation in cellular energy transduction to meet the demands of the organism. Obesity elicits changes in skeletal muscle structure and function, resulting in the accumulation of intramuscular lipids. The accumulation of intramuscular lipids in obesity is associated with impaired skeletal muscle mitochondrial content and function. Mitochondria exist as a dynamic network that is regulated by the processes of biogenesis, fusion, fission, and mitophagy. In this review, we outline adaptations in molecular pathways that regulate mitochondrial structure and function in obesity. We highlight the emerging role of dysregulated skeletal muscle macroautophagy and mitochondrial turnover in obesity. Future research should further elucidate the role of mitophagy in observed reductions in mitochondrial content and function during obesity.

Keywords: biogenesis; dynamics; mitochondria; mitophagy; obesity.

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References

REFERENCES

1. Organization WH. Obesity and overweight: World Health Organization. (2018). 2019.
1. Wang YC, McPherson K, Marsh T, Gortmaker SL, Brown M. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet. 2011;378(9793):815-825.
1. Gallagher D, Heymsfield SB, Heo M, Jebb SA, Murgatroyd PR, Sakamoto Y. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am J Clin Nutr. 2000;72(3):694-701.
1. Heymsfield SB, Wadden TA. Mechanisms, pathophysiology, and management of obesity. N Engl J Med. 2017;376(3):254-266.
1. Bray GA, Frühbeck G, Ryan DH, Wilding JPH. Management of obesity. Lancet. 2016;387(10031):1947-1956.

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[1] Organization WH. Obesity and overweight: World Health Organization. (2018). 2019.

[2] Organization WH. Obesity and overweight: World Health Organization. (2018). 2019.

[3] Wang YC, McPherson K, Marsh T, Gortmaker SL, Brown M. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet. 2011;378(9793):815-825.

[4] Wang YC, McPherson K, Marsh T, Gortmaker SL, Brown M. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet. 2011;378(9793):815-825.

[5] Gallagher D, Heymsfield SB, Heo M, Jebb SA, Murgatroyd PR, Sakamoto Y. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am J Clin Nutr. 2000;72(3):694-701.

[6] Gallagher D, Heymsfield SB, Heo M, Jebb SA, Murgatroyd PR, Sakamoto Y. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am J Clin Nutr. 2000;72(3):694-701.

[7] Heymsfield SB, Wadden TA. Mechanisms, pathophysiology, and management of obesity. N Engl J Med. 2017;376(3):254-266.

[8] Heymsfield SB, Wadden TA. Mechanisms, pathophysiology, and management of obesity. N Engl J Med. 2017;376(3):254-266.

[9] Bray GA, Frühbeck G, Ryan DH, Wilding JPH. Management of obesity. Lancet. 2016;387(10031):1947-1956.

[10] Bray GA, Frühbeck G, Ryan DH, Wilding JPH. Management of obesity. Lancet. 2016;387(10031):1947-1956.

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The lifecycle of skeletal muscle mitochondria in obesity

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The lifecycle of skeletal muscle mitochondria in obesity

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