Association between admission blood fibrinogen-to-albumin ratio and clinical outcomes after acute lacunar stroke

Biomark Med. 2021 Feb;15(2):87-96. doi: 10.2217/bmm-2019-0537. Epub 2021 Jan 14.

Abstract

Aim: We aimed to investigate the influence of admission fibrinogen-to-albumin ratio (FAR) on 3-month outcomes after acute lacunar stroke. Materials & methods: Consecutive patients with acute lacunar stroke were included and classified into two groups according to an optimized FAR cut-off value determined by receiver operating characteristic curve analysis. Results: Compared with those with low FAR (<0.077), patients from the high FAR group (≥0.077) had significantly higher risk for 3-month disability and the composite outcome of death/disability. After logistic regression adjustment, high FAR was still significantly associated with 3-month disability and death/disability. Conclusion: FAR ≥0.077 on admission might be an independent predictor of disability and death/disability at 3 months after lacunar stroke, which needs to be verified in future studies.

Keywords: albumin; death; disability; fibrinogen; lacunar stroke.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Ischemia
  • Fibrinogen
  • Hospitalization
  • Humans
  • Male
  • Middle Aged
  • ROC Curve
  • Risk Factors
  • Stroke, Lacunar*

Substances

  • Fibrinogen