The role of 18 F-FDG PET/CT in retroperitoneal sarcomas-A multicenter retrospective study

J Surg Oncol. 2021 Mar;123(4):1081-1087. doi: 10.1002/jso.26379. Epub 2021 Jan 14.

Abstract

Background: The role of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) in the evaluation of retroperitoneal sarcomas is poorly defined. We evaluated the correlation of maximum standardized uptake value (SUVmax) with pathologic tumor grade in the surgical specimen of primary retroperitoneal dedifferentiated liposarcoma (DDLPS) and leiomyosarcoma (LMS).

Methods: Patients with the above histological subtypes in three participating institutions with preoperative 18 F-FDG PET/CT scan and histopathological specimen available for review were included. The association between SUVmax and pathological grade was assessed. Correlation between SUVmax and relapse-free survival (RFS) and overall survival (OS) were also studied.

Results: Of the total 58 patients, final pathological subtype was DDLPS in 44 (75.9%) patients and LMS in 14 (24.1%) patients. The mean SUVmax was 8.7 with a median 7.1 (range, 2.2-33.9). The tumors were graded I, II, III in 6 (10.3%), 35 (60.3%), and 17 (29.3%) patients, respectively. There was an association of higher histological grade with higher SUVmax (rs = 0.40, p = .002). Increasing SUVmax was associated with worse RFS (p = .003) and OS (p = .003).

Conclusion: There is a correlation between SUVmax and pathologic tumor grade; increasing SUVmax was associated with worse OS and RFS, providing a preoperative noninvasive surrogate marker of tumor grade and biological behavior.

Keywords: PET scan; retroperitoneal; soft tissue tumor.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Fluorodeoxyglucose F18 / metabolism
  • Follow-Up Studies
  • Humans
  • Leiomyosarcoma / diagnostic imaging
  • Leiomyosarcoma / mortality*
  • Leiomyosarcoma / pathology
  • Leiomyosarcoma / surgery
  • Liposarcoma / diagnostic imaging
  • Liposarcoma / mortality*
  • Liposarcoma / pathology
  • Liposarcoma / surgery
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / diagnostic imaging
  • Neoplasm Recurrence, Local / mortality*
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / surgery
  • Positron Emission Tomography Computed Tomography / methods*
  • Prognosis
  • Radiopharmaceuticals / metabolism
  • Retroperitoneal Neoplasms / diagnostic imaging
  • Retroperitoneal Neoplasms / mortality*
  • Retroperitoneal Neoplasms / pathology
  • Retroperitoneal Neoplasms / surgery
  • Retrospective Studies
  • Survival Rate

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18

Supplementary concepts

  • Retroperitoneal liposarcoma