A comprehensive review on the biological interest of quinoline and its derivatives

Bioorg Med Chem. 2021 Feb 15:32:115973. doi: 10.1016/j.bmc.2020.115973. Epub 2020 Dec 31.

Abstract

Amongst heterocyclic compounds, quinoline is an advantaged scaffold that appears as a significant assembly motif for the development of new drug entities. Quinoline and its derivatives tested with diverse biological activity constitute an important class of compounds for new drug development. Therefore, many scientific communities have developed these compounds as intent structure and evaluated their biological activities. The present, review provides brief natural sources of quinoline and including a new extent of quinoline-based marketed drugs. This review also confers information about the biological activities of quinoline derivatives such as antibacterial, antifungal, antimycobacterial, antiviral, anti-protozoal, antimalarial, anticancer, cardiovascular, CNS effects, antioxidant, anticonvulsant, analgesic, anti-inflammatory, anthelmintic and miscellaneous activities.

Keywords: Approved drugs; Biological Interest; Heterocyclic compounds; Marketed drugs; Natural sources; Quinolines.

Publication types

  • Review

MeSH terms

  • Analgesics / chemistry
  • Analgesics / pharmacology*
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology*
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Antiprotozoal Agents / chemistry
  • Antiprotozoal Agents / pharmacology*
  • Humans
  • Molecular Structure
  • Quinolines / chemistry
  • Quinolines / pharmacology

Substances

  • Analgesics
  • Anti-Infective Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antineoplastic Agents
  • Antioxidants
  • Antiprotozoal Agents
  • Quinolines
  • quinoline