Long-term corneal endothelial changes after intraocular lens implantation

Am J Ophthalmol. 1988 Mar 15;105(3):248-52. doi: 10.1016/0002-9394(88)90004-9.


We studied the morphologic characteristics of the corneal endothelium in a series of patients who had undergone phacoemulsification with intraocular lens implantation performed by one surgeon. Specular microscopy and computer-assisted morphometry were performed preoperatively and three years after surgery. Nineteen eyes that received posterior chamber lenses with intracapsular fixation had a mean endothelial cell loss of 18.1%, without any significant change in cell size (polymegethism) or shape variability (pleomorphism). Implantation of anterior chamber lenses with the posterior capsule left intact (18 eyes) caused a similar degree of cell loss (23.5%) but caused marked polymegethism and pleomorphism of the cells. Endothelial cell loss (28.5%) and morphologic changes were greatest in five eyes that received anterior chamber lenses because of a rupture of the posterior capsule.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cataract Extraction
  • Cell Count
  • Endothelium, Corneal / pathology*
  • Follow-Up Studies
  • Humans
  • Lenses, Intraocular*
  • Postoperative Period
  • Time Factors