Isoflurane as an alternative to halothane for caesarean section

Anaesthesia. 1988 Jan;43(1):5-7. doi: 10.1111/j.1365-2044.1988.tb05412.x.


Two series of 25 patients who underwent elective Caesarean section with general anaesthesia were given either 0.75% isoflurane or 0.5% halothane as supplements to 50% nitrous oxide in oxygen used for maintenance. The potent inhalational agent was given for the entire operative period and no case of intra-operative dreaming or awareness was reported. The infusion dose of suxamethonium was significantly less with isoflurane, 50 micrograms/kg/minute (SD 17), as compared to halothane, 64 micrograms/kg/minute (SD 24) (p less than 0.02). Recovery from anaesthesia was more rapid with isoflurane. The surgeon's assessment of uterine relaxation and bleeding using a visual analogue score indicated that this was significantly less with isoflurane. Infant well-being as judged by Apgar score and cord blood gas analysis, showed little difference between the two inhalational agents.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anesthesia, General
  • Anesthesia, Obstetrical*
  • Apgar Score
  • Cesarean Section*
  • Female
  • Halothane*
  • Humans
  • Infant, Newborn
  • Isoflurane*
  • Pregnancy


  • Isoflurane
  • Halothane