Expanding the link between circadian rhythms and redox metabolism of epigenetic control

Tomoki Sato; Carolina Magdalen Greco

doi:10.1016/j.freeradbiomed.2021.01.009

Expanding the link between circadian rhythms and redox metabolism of epigenetic control

Free Radic Biol Med. 2021 Jul:170:50-58. doi: 10.1016/j.freeradbiomed.2021.01.009. Epub 2021 Jan 12.

Authors

Tomoki Sato¹, Carolina Magdalen Greco²

Affiliations

¹ Department of Biological Chemistry, Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine, CA, 92697, USA.
² Department of Biological Chemistry, Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine, CA, 92697, USA. Electronic address: grecoc@uci.edu.

PMID: 33450380
DOI: 10.1016/j.freeradbiomed.2021.01.009

Abstract

Circadian rhythms play a central role in physiological and metabolic processes. This is mostly achieved through rhythmic regulation of myriad genes via dynamic epigenome changes. Accumulating evidence indicates that oxidative stress and redox balance are under circadian control and feedback on the clock system. Circadian perturbations induce oxidative stress accumulation and disturb redox balance. Along with these changes, epigenomic landscape changes are a remarkable hallmark of clock disruption. This review aims to summarize evidence supporting the link between the circadian clock and redox metabolism, focusing on possible connections through epigenetic mechanisms.

Keywords: Circadian clock; Epigenome landmark; Histone modification; Oxidative stress.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Circadian Clocks* / genetics
Circadian Rhythm* / genetics
Epigenesis, Genetic
Epigenomics
Oxidation-Reduction

Grants and funding

T32 CA009054/CA/NCI NIH HHS/United States